Introduction: Depression is a common and potential disabling factor in infertile females. The aim of the present research was to examine the relationship between cognitive emotion regulation strategies and resilience, and depression of infertile females.

Methods: This research was a correlational study. The sample of the present study included three hundred infertile females referred to the infertility institution of Tabriz Jahad University, which were selected using the random sampling method. For collecting the data, Garnefski cognitive emotion regulation scale, Conner resilience questionnaire and Beck depression inventory were used. The data were analyzed with Pearson correlation test and multiple regression analysis and SPSS software version 22. The P value was considered significant at 0.05.

Results: There was a positive relationship between depression of infertile females and self-blame, others-blame, preoccupation, catastrophizing, and putting into perspective, and there was a negative significant relationship with resilience, renewed positive concentration, renewed positive appraisal, acceptance and renewed concentration on scheduling. The results of multivariate correlation coefficient through the Enter method showed that variable resilience and cognitive emotion regulation had a role (R2 = 49.1%) in explaining depression in infertile females.

Conclusions: In accordance with the reverse relationship between depression in infertile females and resilience and cognitive emotion regulation strategies, it seems that resilience and adaptive cognitive emotion regulation strategies can lead to a decrease in depression in infertile females.